Interactions of Shiga-like toxin with human peripheral blood monocytes
نویسندگان
چکیده
منابع مشابه
Shiga Toxin Interaction with Human Intestinal Epithelium
After ingestion via contaminated food or water, enterohaemorrhagic E. coli colonises the intestinal mucosa and produces Shiga toxins (Stx). No Stx-specific secretion system has been described so far, and it is assumed that Stx are released into the gut lumen after bacterial lysis. Human intestinal epithelium does not express the Stx receptor Gb3 or other Stx binding sites, and it remains unknow...
متن کاملLack of specific binding of Shiga-like toxin (verocytotoxin) and non-specific interaction of Shiga-like toxin 2 antibody with human polymorphonuclear leucocytes.
BACKGROUND After gastrointestinal infection with Shiga-like toxin (Stx) producing Escherichia coli, the toxin is transported from the intestine to the renal microvascular endothelium. This is the main target for Stx in humans. Previous studies indicated that polymorphonuclear leucocytes (PMN) could serve as carriers for Stx in the systemic circulation. As at a later stage we could not confirm t...
متن کاملOnly a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity.
The monocyte population in blood is considered a possible source of endothelial precursors. Because endothelial-specific receptor tyrosine kinases act as regulators of endothelial cell function, we investigated whether expression of the vascular endothelial growth factor receptor-2 (VEGFR-2) on monocytes is important for their endothelial-like functional capacity. Peripheral-blood monocytes exp...
متن کاملDemonstration of Sarcocystis-like Parasites Found in Peripheral Blood
This report described Sarcocystis-like merozoites in peripheral blood smear of a woman with mild fever, rigor and musculoskeletal pain. Extracellular organisms with a pale blue cytoplasm and one or two nuclei were seen in her blood smear stained with Giemsa. Sarcocystis-like can be considered as a possible cause of some idiopathic febrile diseases.
متن کاملInduction of tissue transglutaminase in human peripheral blood monocytes
The levels and activity of tissue transglutaminase were studied in human peripheral blood monocytes during differentiation into macrophages in vitro. The enzyme was present at low levels in freshly isolated monocytes (less than 20 ng/mg cell protein) but increased 50-fold during 10 d of adherent culture in autologous serum, reaching levels of 0.1% of total cellular protein. The rate of appearan...
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ژورنال
عنوان ژورنال: Pediatric Nephrology
سال: 2007
ISSN: 0931-041X,1432-198X
DOI: 10.1007/s00467-007-0512-4